Hydrochloric Acid → HCID 18321245, compound

HRID 1782699Notes

Reaction equation

HRID 1782699 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:8](=[O:17])[NH:9][C:10]3[C:15]([CH:16]=2)=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:3][CH:2]=1.[ClH:18]>[Pt](=O)=O.C(O)C>[ClH:18].[NH:1]1[CH2:2][CH2:3][CH:4]([CH:7]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][C:8]2=[O:17])[CH2:5][CH2:6]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 18321205HCID 18321205, compound

Product 1

HCID 18321245HCID 18321245, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

A mixture of 1.1 g (4.949 mmol) of 3-(4-pyridinyl)-2(1H)-quinolone (D. R. Bragg and D. G. Wibberley, J. Chem. Soc. 1961, 5074-5077), 100 ml of ethanol, 5 ml (5 mmol) of 1N hydrochloric acid and 0.2 g platinum (IV) oxide was hydrogenated for 4 hours at room temperature. The catalyst was filtered off, the filtrate evaporated down in vacuo and the residue was triturated with isopropanol. The precipitated crystals were suction filtered, washed with isopropanol and diethylether and dried in vacuo. Yield: 0.64 g (56.2% of theory).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated down in vacuo
  3. customthe residue was triturated with isopropanol
  4. filtrationfiltered
  5. washwashed with isopropanol and diethylether
  6. customdried in vacuo

Sources & evidence

ORD record
ord-87cef751482546b88fce41513d644f7c
Source dataset
uspto-grants-2009_03
Patent number
US07498325B2

Reaction notes

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