Hexahydro-1-methyl-4-[1-(phenylmethyl)-4-piperidinyl]-1H-1,4-diazepine → Hexahydro-1-methyl-4-(4-piperidinyl)-1H-1 4-diazepine

HRID 1782722Notes

Reaction equation

HRID 1782722 reaction equation
[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([CH:9]2[CH2:14][CH2:13][N:12](CC3C=CC=CC=3)[CH2:11][CH2:10]2)[CH2:4][CH2:3]1>[OH-].[OH-].[Pd+2]>[CH3:1][N:2]1[CH2:8][CH2:7][CH2:6][N:5]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH2:4][CH2:3]1

Participants

3

Reactant 1

HCID 18321160Hexahydro-1-methyl-4-[1-(phenylmethyl)-4-piperidinyl]-1H-1,4-diazepine

Product 1

HCID 18321176Hexahydro-1-methyl-4-(4-piperidinyl)-1H-1 4-diazepine

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

Prepared analogously to Example A3f) from hexahydro-1-methyl-4-[1-(phenylmethyl)-4-piperidinyl]-1H-1,4-diazepine by hydrogenolysis, but using Pearlman's catalyst instead of palladium/charcoal, in a quantitative yield. Colourless viscous oil.

Sources & evidence

ORD record
ord-94fcb51b47c845f0ae6891a69974f9e6
Source dataset
uspto-grants-2009_03
Patent number
US07498325B2

Reaction notes

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