HRID1782778

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COC(=O)c1ccc(OCCCc2ccc(OCCCC3OCC(C)(C)CO3)cc2)c(C(=O)NC2CCCC(C(=O)OC)C2)c1

HCID57589102

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(OCCCc2ccc(OCCCC3OCC(C)(C)CO3)cc2)c(C(=O)NC2CCCC(C(=O)O)C2)c1

HCID69075955

未命名化合物

收率 77.9%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID8028

Tetrahydrofuran

C4H8O

溶剂HCID14798

Sodium Hydroxide

HNaO

PROCEDURE

实验过程

A solution of 70.0 mg of methyl 4-(3-{4-[3-(5,5-dimethyl-1,3-dioxan-2-yl)propoxy]-phenyl}propoxy)-3-({[3-(methoxycarbonyl)cyclohexyl]amino}carbonyl)benzoate in 1 ml each of methanol, THF and 2 molar sodium hydroxide solution is stirred at a temperature of 60° C. for 2 hours. Then 1.1 ml of 2 molar hydrochloric acid are added, and the reaction mixture is left to stand open at room temperature for 15 hours. A precipitate separates out and is filtered off with suction and washed with water. If the precipitation is incomplete, extraction with ethyl acetate is possible. The organic extract is dried over anhydrous sodium sulphate and evaporated. 53.3 mg of a solid are obtained.

WORKUP

后处理

waitthe reaction mixture is left
filtrationis filtered off with suction
washwashed with water
customIf the precipitation
extractionextraction with ethyl acetate
extractionThe organic extract
dry with materialis dried over anhydrous sodium sulphate
customevaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-99804e3a40f3441b94044a379b018da5
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07498460B2
来源说明: uspto-grants-2009_03

反应 SMILES

[CH3:1][C:2]1([CH3:45])[CH2:7][O:6][CH:5]([CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][CH2:20][O:21][C:22]3[CH:31]=[CH:30][C:25]([C:26]([O:28][CH3:29])=[O:27])=[CH:24][C:23]=3[C:32]([NH:34][CH:35]3[CH2:40][CH2:39][CH2:38][CH:37]([C:41]([O:43]C)=[O:42])[CH2:36]3)=[O:33])=[CH:14][CH:13]=2)[O:4][CH2:3]1.Cl>CO.C1COCC1.[OH-].[Na+]>[C:41]([CH:37]1[CH2:38][CH2:39][CH2:40][CH:35]([NH:34][C:32]([C:23]2[CH:24]=[C:25]([CH:30]=[CH:31][C:22]=2[O:21][CH2:20][CH2:19][CH2:18][C:15]2[CH:16]=[CH:17][C:12]([O:11][CH2:10][CH2:9][CH2:8][CH:5]3[O:4][CH2:3][C:2]([CH3:45])([CH3:1])[CH2:7][O:6]3)=[CH:13][CH:14]=2)[C:26]([O:28][CH3:29])=[O:27])=[O:33])[CH2:36]1)([OH:43])=[O:42]