反应详情

温度

95 °C

Hydrazine monohydrate (6.8 ml, 0.14 mol) was dissolved in EtOH (10 ml) and cooled to 0° C. (1-Ethoxyethylidene)malononitrile (10 g, 0.073 mol) was added slowly and the mixture was heated at 95° C. for 2 h. After cooling to rt, water (20 ml) was added and the mixture was allowed to stand at rt overnight. The mixture was concentrated under reduced pressure and the resulting residue treated with EtOH (6 ml) and water (6 ml). After cooling in an ice/water bath for 10 min, the resulting precipitate was collected by filtration to give 6.34 g of 5-amino-3-methyl-1H-pyrazole-4-carbonitrile.

1. additionwas added slowly
2. temperatureAfter cooling to rt
3. concentrationThe mixture was concentrated under reduced pressure
4. additionthe resulting residue treated with EtOH (6 ml) and water (6 ml)
5. temperatureAfter cooling in an ice/water bath for 10 min
6. filtrationthe resulting precipitate was collected by filtration