Tetrahydrofuran → 6-chloro-N-(cyanomethyl)-N-[1-(1-morpholin-4-yl-1-oxopropan-2-yl)-2-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
Reaction equation
[Br:42][CH2:43][C:44]#[N:45].[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[CH3:32][Si:33]([N-:34][Si:35]([CH3:36])([CH3:37])[CH3:38])([CH3:39])[CH3:40].[Cl:1][c:2]1[cH:3][c:4]2[cH:5][cH:6][c:7]([S:12](=[O:13])(=[O:14])[NH:15][CH:16]3[C:17](=[O:31])[N:18]([CH:21]([C:22](=[O:23])[N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)[CH3:30])[CH2:19][CH2:20]3)[cH:8][c:9]2[cH:10][cH:11]1.[Li+:41]>>[Cl:1][c:2]1[cH:3][c:4]2[cH:5][cH:6][c:7]([S:12](=[O:13])(=[O:14])[N:15]([CH:16]3[C:17](=[O:31])[N:18]([CH:21]([C:22](=[O:23])[N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)[CH3:30])[CH2:19][CH2:20]3)[CH2:43][C:44]#[N:45])[cH:8][c:9]2[cH:10][cH:11]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-2b4d84b8edc044dbbf8d2d0c60320210
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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