Trifluoroacetic acid → HCID 68602341, compound

HRID 1783432Notes

Reaction equation

HRID 1783432 reaction equation
C(OC([N:8](C(OC(C)(C)C)=O)[C:9]1[CH:14]=[C:13]([CH2:15][C@H:16]2[C:19](=[O:20])[N:18]([C:21]([NH:23][C@@H:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH3:25])=[O:22])[C@@H:17]2[C:32]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])=[O:33])[CH:12]=[CH:11][N:10]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[NH2:8][C:9]1[CH:14]=[C:13]([CH2:15][C@H:16]2[C:19](=[O:20])[N:18]([C:21]([NH:23][C@@H:24]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[CH3:25])=[O:22])[C@@H:17]2[C:32]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])=[O:33])[CH:12]=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68601928HCID 68601928, compound

Product 1

HCID 68602341HCID 68602341, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 95 in 1 mL dichloromethane was added 300 uL of TFA. The reaction was stirred for 1 hour and then concentrated in vacuo. The crude material was purified via reverse phase HPLC (C18, acetonitrile/water with 0.1% TFA) to yield 0.75 mg of 96. MS [M+H]+=446.0

Workup

  1. concentrationconcentrated in vacuo
  2. customThe crude material was purified via reverse phase HPLC (C18, acetonitrile/water with 0.1% TFA)

Sources & evidence

ORD record
ord-4050746a657246f083fa41a02d1b514e
Source dataset
uspto-grants-2009_03
Patent number
US07501404B2

Reaction notes

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