Sodium Carbonate → HCID 57590542, compound

HRID 1783468Notes

Reaction equation

HRID 1783468 reaction equation
[C:1]1([C:7]2[NH:11][N:10]=[N:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:12]([O:16][C:17]([N:19]1[CH2:23][CH:22](OS(C2C=CC(C)=CC=2)(=O)=O)[CH2:21][CH:20]1[C:35](N1CCN(C2C=CC=CC=2C#N)CC1)=[O:36])=[O:18])([CH3:15])([CH3:14])[CH3:13].[C:51](=O)([O-])[O-:52].[Na+].[Na+]>CN(C=O)C.CC(=O)OCC>[CH3:51][O:52][C:35]([CH:20]1[CH2:21][CH:22]([N:9]2[N:10]=[N:11][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[N:8]2)[CH2:23][N:19]1[C:17]([O:16][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:18])=[O:36]

Participants

6

Reactant 3

HCID 10340Sodium CarbonateHCID 86625266HCID 86625266, compoundHCID 178418369HCID 178418369, compound

Product 1

HCID 57590542HCID 57590542, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of a corresponding phenyl-tetrazole in DMF is added 2-[4-(2-cyano-phenyl)-piperazine-1-carbonyl]-4-(toluene-4-sulfonyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester and anhydrous sodium carbonate. The mixture is stirred at about 60 degree overnight. The solution is diluted with EA, washed, dried and concentrated to give the corresponding 4-[5-(phenyl)-tetrazol-2-yl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (4).

Workup

  1. washwashed
  2. customdried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-b48f535d7fd94fe4abb81e3ef75e2c78
Source dataset
uspto-grants-2009_03
Patent number
US07501422B2

Reaction notes

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