Trifluoroacetic acid → HCID 9931237, compound

HRID 1783523Notes

Reaction equation

HRID 1783523 reaction equation
[CH3:1][N:2]([CH3:30])[CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]3[N:21]=[C:20]4[N:22]([CH:27]([CH3:29])[CH3:28])[C:23](=[O:26])[NH:24][CH2:25][C:19]4=[CH:18][N:17]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.CC(C)([O-])C.[K+]>O1CCCC1>[CH3:1][N:2]([CH3:30])[CH:3]1[CH2:4][CH2:5][N:6]([C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]3[N:21]=[C:20]4[N:22]([CH:27]([CH3:28])[CH3:29])[C:23](=[O:26])[N:24]=[CH:25][C:19]4=[CH:18][N:17]=3)=[CH:11][CH:10]=2)[CH2:7][CH2:8]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 23665647Potassium tert-butoxideHCID 68860425HCID 68860425, compound

Product 1

HCID 9931237HCID 9931237, compoundYield 19%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 200 mg (0.31 mmol) of 7-{4-[4-(dimethylamino)piperidin-1-yl]phenylamino}-1-isopropyl-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one, trifluoroacetic acid and 211 mg (1.88 mmol) of potassium tert-butoxide in 7 mL of tetrahydrofuran. The reaction mixture is stirred for 48 hours, and the workup is done as described in the general procedure, then the reaction is repeated for 72 hours. After the workup, the semi-solid is triturated in diethyl ether, and the powder is collected and dried to give 24 mg (18%) of the title compound:

Workup

  1. waitthe reaction is repeated for 72 hours
  2. customAfter the workup, the semi-solid is triturated in diethyl ether
  3. customthe powder is collected
  4. customdried

Sources & evidence

ORD record
ord-b949ae9160ae4c59ae38aaabb1cfeb00
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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