Trifluoroacetic acid → HCID 9906445, compound

HRID 1783527Notes

Reaction equation

HRID 1783527 reaction equation
[CH3:1][N:2]1[C:7]2=[N:8][C:9]([NH:12][C:13]3[CH:18]=[CH:17][C:16]([N:19]4[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]4)=[CH:15][CH:14]=3)=[N:10][CH:11]=[C:6]2[CH2:5][NH:4][C:3]1=[O:26].FC(F)(F)C(O)=O.CC(C)([O-])C.[K+]>O1CCCC1>[CH3:1][N:2]1[C:7]2=[N:8][C:9]([NH:12][C:13]3[CH:14]=[CH:15][C:16]([N:19]4[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]4)=[CH:17][CH:18]=3)=[N:10][CH:11]=[C:6]2[CH:5]=[N:4][C:3]1=[O:26]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 23665647Potassium tert-butoxideHCID 68859244HCID 68859244, compound

Product 1

HCID 9906445HCID 9906445, compoundYield 62.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 250 mg (0.50 mmol) of 1-methyl-7-[4-(4-methylpiperazin-1-yl)phenylamino]-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one, trifluoroacetic acid and 336 mg (2.99 mmol) of potassium tert-butoxide in 12 mL of tetrahydrofuran. The reaction mixture is stirred for 48 hours. After the workup, the semi-solid is triturated in diethyl ether, and the powder is collected and dried to give 110 mg (61%) of the title compound: mp 259-260° C. (dec).

Workup

  1. customAfter the workup, the semi-solid is triturated in diethyl ether
  2. customthe powder is collected
  3. customdried

Sources & evidence

ORD record
ord-418a8bb1d9cd4d4094b40707213f97e4
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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