2-Aminothiazole → HCID 178518046, compound

HRID 1783617Notes

Reaction equation

HRID 1783617 reaction equation
CS[C:3]1[S:4][C:5](=[CH:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][N:14]=[CH:13]3)[C:6](=[O:8])[N:7]=1.[S:20]1[CH:24]=[CH:23][N:22]=[C:21]1[NH2:25].CCN(C(C)C)C(C)C>>[N:16]1[C:17]2[C:12](=[CH:11][C:10](/[CH:9]=[C:5]3/[C:6](=[O:8])[N:7]=[C:3]([NH:25][C:21]4[S:20][CH:24]=[CH:23][N:22]=4)[S:4]/3)=[CH:19][CH:18]=2)[CH:13]=[N:14][CH:15]=1

Participants

4

Reactant 3

HCID 21552-AminothiazoleHCID 81531DiisopropylethylamineHCID 68819203HCID 68819203, compound

Product 1

HCID 178518046HCID 178518046, compound

Procedure

Similar procedure as described in example 1d was used, starting from 2-methylsulfanyl-5-quinazolin-6-ylmethylene-thiazol-4-one, thiazol-2-ylamine and DIEA to give 5-[1-quinazolin-6-yl-meth-(Z)-ylidene]-2-(thiazol-2-ylamino)-thiazol-4-one: LC-MS m/e observed. LC-MS m/e 340 (MH+).

Sources & evidence

ORD record
ord-c1bc7c12f282409c8a90a8a2a9661ac0
Source dataset
uspto-grants-2009_03
Patent number
US07501428B2

Reaction notes

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