o-Phenetidine → HCID 178466193, compound

HRID 1783619Notes

Reaction equation

HRID 1783619 reaction equation
CS[C:3]1[S:4][C:5](=[CH:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][N:14]=[CH:13]3)[C:6](=[O:8])[N:7]=1.[CH2:20]([O:22][C:23]1[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=1[NH2:25])[CH3:21].CCN(C(C)C)C(C)C>>[CH2:20]([O:22][C:23]1[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=1[NH:25][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][N:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1)[CH3:21]

Participants

4

Reactant 3

HCID 7203o-PhenetidineHCID 81531DiisopropylethylamineHCID 68819203HCID 68819203, compound

Product 1

HCID 178466193HCID 178466193, compound

Procedure

Similar procedure as described in example 1d was used, starting from 2-methylsulfanyl-5-quinazolin-6-ylmethylene-thiazol-4-one, 2-ethoxyaniline and DIEA to give 2-(2-ethoxy-phenylamino)-5-[1-quinazolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one: LC-MS m/e observed. LC-MS m/e 377 (MH+).

Sources & evidence

ORD record
ord-89c120392ee84e0b89b32e9f07b48acb
Source dataset
uspto-grants-2009_03
Patent number
US07501428B2

Reaction notes

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