2,4-Dimethoxyaniline → HCID 178492209, compound

HRID 1783623Notes

Reaction equation

HRID 1783623 reaction equation
CS[C:3]1[S:4][C:5](=[CH:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][N:14]=[CH:13]3)[C:6](=[O:8])[N:7]=1.[CH3:20][O:21][C:22]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=1[NH2:30].CCN(C(C)C)C(C)C>>[CH3:20][O:21][C:22]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:23]=1[NH:30][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][N:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1

Participants

4

Reactant 3

HCID 176522,4-DimethoxyanilineHCID 81531DiisopropylethylamineHCID 68819203HCID 68819203, compound

Product 1

HCID 178492209HCID 178492209, compound

Procedure

Similar procedure as described in example 1d was used, starting from 2-methylsulfanyl-5-quinazolin-6-ylmethylene-thiazol-4-one, 2,4-dimethoxy-phenylamine and DIEA to give 2-(2,4-dimethoxy-phenylamino)-5-[1-quinazolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one: LC-MS m/e observed. LC-MS m/e 393 (MH+).

Sources & evidence

ORD record
ord-3119269796b14e2ebfff7ec9656a3dfe
Source dataset
uspto-grants-2009_03
Patent number
US07501428B2

Reaction notes

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