Potassium Carbonate → HCID 16788087, compound

HRID 1783751Notes

Reaction equation

HRID 1783751 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[N:11]1(C(O)=O)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.[C:20]([O-])([O-:22])=[O:21].[K+].[K+].CN1C(=O)CCC1>O>[N+:8]([C:7]1[C:2]([N:11]2[CH2:12][CH2:13][CH:14]([C:20]([OH:22])=[O:21])[CH2:15][CH2:16]2)=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

Participants

6

Reactant 4

HCID 11430Potassium CarbonateHCID 13387N-methyl-2-pyrrolidoneHCID 796132-Chloro-3-nitropyridineHCID 9964094Piperidine-1-carboxylic acid

Product 1

HCID 16788087HCID 16788087, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
80 °C

Procedure

The mixture consisting of 634 mg of 2-chloro-3-nitropyridine, 620 mg of piperidine carboxylic acid, 820 mg of potash and 3 ml of NMP was stirred at 80° C. for 2 hours. After allowing to cool, 30 ml of water of water were added and the crude product was extracted with 30 ml of ethyl acetate. After drying the organic phase with sodium sulfate, it was concentrated under reduced pressure.

Workup

  1. temperatureto cool
  2. extractionthe crude product was extracted with 30 ml of ethyl acetate
  3. dry with materialAfter drying the organic phase with sodium sulfate, it
  4. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-167c65b36ef045c2878dd95c113c12bc
Source dataset
uspto-grants-2009_03
Patent number
US07501440B2

Reaction notes

Loading…