Dimethylformamide → HCID 69081378, compound

HRID 1783753Notes

Reaction equation

HRID 1783753 reaction equation
[Cl:1][C:2]1[CH:28]=[C:27]([F:29])[C:26]([F:30])=[CH:25][C:3]=1[C:4]([NH:6][C:7](=[O:24])[NH:8][C:9]1[C:10]([N:15]2[CH2:20][CH2:19][CH:18]([C:21]([OH:23])=O)[CH2:17][CH2:16]2)=[N:11][CH:12]=[CH:13][CH:14]=1)=[O:5].C[N:32](C=O)C.[Cl-].[NH4+].CCN(C(C)C)C(C)C>O>[Cl:1][C:2]1[CH:28]=[C:27]([F:29])[C:26]([F:30])=[CH:25][C:3]=1[C:4]([NH:6][C:7](=[O:24])[NH:8][C:9]1[C:10]([N:15]2[CH2:16][CH2:17][CH:18]([C:21]([NH2:32])=[O:23])[CH2:19][CH2:20]2)=[N:11][CH:12]=[CH:13][CH:14]=1)=[O:5]

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 25517Ammonium ChlorideHCID 81531DiisopropylethylamineHCID 9954844HCID 9954844, compound

Product 1

HCID 69081378HCID 69081378, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The mixture consisting of 50 mg of 3′-[3-(2-chloro-4,5-difluorobenzoyl)ureido]-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid, 0.5 ml of DMF, 6.1 mg of ammonium chlorid, 40 μl of Hunig's base and 37.3 mg of Totu was stirred at room temperature for 2 hours. Afterwards, it was diluted with 5 ml of water and the mixture was stirred briefly. The precipitate was filtered of with suction and dried under reduced pressure.

Workup

  1. stirringthe mixture was stirred briefly
  2. filtrationThe precipitate was filtered of with suction
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-7b240956428b41c69bc0ee351e85c0e9
Source dataset
uspto-grants-2009_03
Patent number
US07501440B2

Reaction notes

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