反应详情

A solution of 4-[4-(5-bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-phenyl]-3-oxo-piperazine-1-carboxylic acid tert-butyl ester (0.252 mg, 0.6 mmol) in 2:1 DCM:TFA (4.8 mL) is stirred for 1 hour at room temperature. The mixture is then diluted with DCM and basified with sat. NaHCO3. The aqueous layer is extracted with DCM (3×) and the organic layers are combined, dried over MgSO4, filtered and concentrated to afford the title compound as a solid (180 mg, 78%).

1. extractionThe aqueous layer is extracted with DCM (3×)
2. dry with materialdried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated