反应详情

2-Methoxy-4-nitrobenzoic acid (293 mg, 1.49 mmol) is dissolved in DMF (2 mL) and 4-methylmorpholine (220 μL, 3.0 mmol) and TBTU (1.79 g, 1.7 mmol) are added. The mixture is stirred at rt for 30 min and C-(6-methylpyridin-3-yl)methylamine (400 mg, 3.27 mmol) is added. Stirring is continued at rt for 12 h. DCM (10 mL) is added and the organic phase is washed with Na2CO3 (5% aq.), HCl (3% aq.) and water, and then dried over Na2SO4. After evaporation of the solvents, the residue is triturated with ether-hexane to afford the title compound as a white solid.

1. stirringStirring
2. waitis continued at rt for 12 h
3. washthe organic phase is washed with Na2CO3 (5% aq.), HCl (3% aq.) and water
4. dry with materialdried over Na2SO4
5. customAfter evaporation of the solvents
6. customthe residue is triturated with ether-hexane