反应详情

温度

85 °C

5,8-Dibromo-[1,2,4]triazolo[1,5-a]pyrazine (1.39 g, 5.00 mmol) and ethyl 3-aminobenzoate (0.93 g, 5.60 mmol) are stirred in iPrOH (10 mL) and HBr (48% aq., 1.14 mL, 10 mmol) is added. The mixture is heated at 85° C. for 4 h and then cooled to rt and quenched with NaHCO3 (sat. aq., 25 mL). The resulting suspension is cooled to 0° C. and the white solid is collected by suction filtration and washed with water (10 mL). The crude product is taken up in EtOH and the solvent evaporated to afford the title compound as an off-white solid (1.79 g, 4.9 mmol) which is used without further purification.

1. temperaturecooled to rt
2. customquenched with NaHCO3 (sat. aq., 25 mL)
3. temperatureThe resulting suspension is cooled to 0° C.
4. filtrationthe white solid is collected by suction filtration
5. washwashed with water (10 mL)
6. customthe solvent evaporated