反应详情

A mixture of 3 g (8.8 mmol) N-(3,4-Dimethoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamide and 1 g (26.3 mmol) LiAlH4 in 100 mL THF was stirred for 1 h at room temperature. Water and HCl aq. was added and the mixture was extracted with ethyl acetate. The combined organic phases were washed with water, dried with MgSO4 and evaporated to dryness. The residue was purified by flash column chromatography on silica eluting with a gradient formed from ethyl acetate and heptane. The product containing fractions were combined and evaporated to dryness to yield 0.7 g (24%) of the title compound. MS(m/e): 326.1 (MH+).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe combined organic phases were washed with water
3. dry with materialdried with MgSO4
4. customevaporated to dryness
5. customThe residue was purified by flash column chromatography on silica eluting with a gradient
6. customformed from ethyl acetate and heptane
7. additionThe product containing fractions
8. customevaporated to dryness