Hydrochloric Acid → HCID 68863043, compound

HRID 1784236Notes

Reaction equation

HRID 1784236 reaction equation
[CH3:1][O:2][C:3](=[O:32])[C@@H:4]([NH:24]C(OC(C)(C)C)=O)[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:16][CH:15]=2)=[CH:8][CH:7]=1.[ClH:33]>O1CCOCC1>[ClH:33].[CH3:1][O:2][C:3](=[O:32])[C@@H:4]([NH2:24])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([C:20]([CH3:21])([CH3:22])[CH3:23])=[CH:18][CH:19]=2)=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68858769HCID 68858769, compound

Product 1

HCID 68863043HCID 68863043, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(S)-2-Tert-butoxycarbonylamino-3-[4-(4-tert-butyl-benzyloxy)-phenyl]-propionic acid methyl ester (290 mg, 0.66 mmol) was treated with 4 mL of 4N HCl in dioxane for 1 h at room temperature. The solvent was evaporated and the remaining solid triturated with diethyl ether to give (S)-2-amino-3-[4-(4-tert-butyl-benzyloxy)-phenyl]-propionic acid methyl ester-hydrochloride (214 mg).

Workup

  1. customThe solvent was evaporated
  2. customthe remaining solid triturated with diethyl ether

Sources & evidence

ORD record
ord-ecb8d9f7750b4a1a8f7c582587ef1cf5
Source dataset
uspto-grants-2009_03
Patent number
US07501538B2

Reaction notes

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