Hydrochloric Acid → HCID 53628934, compound

HRID 1784657Notes

Reaction equation

HRID 1784657 reaction equation
[ClH:1].[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][N:14]([C:16]3[N:21]([CH3:22])[C:20](=[O:23])[CH:19]=[C:18]([C:24]4[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=4)[N:17]=3)[CH2:13][CH2:12][NH:11]2)=[CH:6][CH:5]=1>C(OCC)(=O)C.ClCCl>[ClH:1].[ClH:1].[CH3:2][O:3][C:4]1[CH:5]=[CH:6][C:7]([CH:10]2[CH2:15][N:14]([C:16]3[N:21]([CH3:22])[C:20](=[O:23])[CH:19]=[C:18]([C:24]4[CH:25]=[CH:26][N:27]=[CH:28][CH:29]=4)[N:17]=3)[CH2:13][CH2:12][NH:11]2)=[CH:8][CH:9]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11153126HCID 11153126, compound

Product 1

HCID 53628934HCID 53628934, compoundYield 96%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

4N Hydrogen chloride in ethyl acetate (5 ml) was added to the solution of 2-(2-(4-methoxyphenyl)-piperazine-4-yl)-3-methyl-6-(4-pyridyl)pyrimidin-4-one (594 mg, 1.6 mmol) in dichloromethane (5 ml) and stirred for 1 hr. Wash with ethyl acetate after removal of the solvent and dryness gave the title compound (683 mg, 96%).

Workup

  1. washWash with ethyl acetate
  2. customafter removal of the solvent and dryness

Sources & evidence

ORD record
ord-1cc5ded6a9224a0f953c34488890b846
Source dataset
uspto-grants-2009_03
Patent number
US07504411B2

Reaction notes

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