Hydrochloric Acid → (S)-2-(4'-methoxybiphen-4-yl) piperazine dihydrochloride

HRID 1784692Notes

Reaction equation

HRID 1784692 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][C@@H:9]1[C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=2)=[CH:23][CH:22]=1)=O)(C)(C)C.[ClH:35]>ClCCl.C(OCC)(=O)C>[ClH:35].[ClH:35].[CH3:34][O:33][C:30]1[CH:31]=[CH:32][C:27]([C:24]2[CH:23]=[CH:22][C:21]([C@H:9]3[CH2:10][NH:11][CH2:12][CH2:13][NH:8]3)=[CH:26][CH:25]=2)=[CH:28][CH:29]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 131727360(S)-1,4-di(t-butoxycarbonyl)-2-(4'-methoxybiphen-4-yl)piperazine

Product 1

HCID 131727361(S)-2-(4'-methoxybiphen-4-yl) piperazine dihydrochlorideYield 94%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of (S)-1,4-di(t-butoxycarbonyl)-2-(4′-methoxybiphen-4-yl)-piperazine (1.46 g, 3.12 mmol) in dichloromethane (8 mL) was added 4 N hydrogen chloride in ethyl acetate (8 mL) at room temperature. After stirring for 1 h, the precipitate was collected and dried in vacuo to afford (S)-2-(4′-methoxybiphen-4-yl) piperazine dihydrochloride (1.00 g, 94%) as white solid.

Workup

  1. customthe precipitate was collected
  2. customdried in vacuo

Sources & evidence

ORD record
ord-f8ca483842b5438b9455a12d784197ec
Source dataset
uspto-grants-2009_03
Patent number
US07504411B2

Reaction notes

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