Hydrochloric Acid → HCID 67117412, compound

HRID 1784699Notes

Reaction equation

HRID 1784699 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH:9]1[C:21]1[CH:26]=[CH:25][C:24]([C:27]2[N:31]=[CH:30][O:29][N:28]=2)=[CH:23][CH:22]=1)=O)(C)(C)C.[ClH:32]>ClCCl.C(OCC)(=O)C>[ClH:32].[ClH:32].[O:29]1[CH:30]=[N:31][C:27]([C:24]2[CH:25]=[CH:26][C:21]([CH:9]3[CH2:10][NH:11][CH2:12][CH2:13][NH:8]3)=[CH:22][CH:23]=2)=[N:28]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 53628951HCID 53628951, compound

Product 1

HCID 67117412HCID 67117412, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 1,4-di(t-butoxycarbonyl)-2-(4-(1,2,4-oxadiazol-3-yl) phenyl)piperazine (464 mg, 1.08 mmol) in dichloromethane (2 mL) was added 4 N hydrogen chloride in ethyl acetate (3 mL) at room temperature. After stirring for 1.5 h, the precipitate was collected and dried in vacuo to afford 2-(4-(1,2,4-oxadiazol-3-yl)phenyl)piperazine dihydrochloride (321 mg, 98%) as a white powder.

Workup

  1. customthe precipitate was collected
  2. customdried in vacuo

Sources & evidence

ORD record
ord-57958516d5ce48d287e37d493ccef38f
Source dataset
uspto-grants-2009_03
Patent number
US07504411B2

Reaction notes

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