Hydrochloric Acid → 6-Amino-3-(4-bromo-phenyl)-hexanoic acid ethyl ester hydrochloride

HRID 1784705Notes

Reaction equation

HRID 1784705 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH2:5][CH:6]([C:18]1[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][CH:19]=1)[CH2:7][CH2:8][CH2:9][NH:10]C(OC(C)(C)C)=O)[CH3:2].[ClH:26]>C(OCC)(=O)C>[ClH:26].[CH2:1]([O:3][C:4](=[O:25])[CH2:5][CH:6]([C:18]1[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][CH:19]=1)[CH2:7][CH2:8][CH2:9][NH2:10])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 671174423-(4-Bromo-phenyl)-6-tert-butoxycarbonylamino-hexanoic acid ethyl ester

Product 1

HCID 671173986-Amino-3-(4-bromo-phenyl)-hexanoic acid ethyl ester hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 3-(4-Bromo-phenyl)-6-tert-butoxycarbonylamino-hexanoic acid ethyl ester (2.43 g, 6.32 mmol) in ethyl acetate (3 mL) was added 4 N hydrogen chloride in ethyl acetate (6 mL) at room temperature. Removal of the solvent in vacuo after stirring for 30 min afforded 6-Amino-3-(4-bromo-phenyl)-hexanoic acid ethyl ester hydrochloride that was used in the next step without further purification.

Workup

  1. customRemoval of the solvent in vacuo

Sources & evidence

ORD record
ord-9b08306b43794c0caae6c50d5fc43b55
Source dataset
uspto-grants-2009_03
Patent number
US07504411B2

Reaction notes

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