2-Amino-5-nitropyridine → 3-Methyl-6-nitroimidazo[1,2-a]pyridine

HRID 1784727Notes

Reaction equation

HRID 1784727 reaction equation
Br[CH:2]([CH3:5])[CH:3]=O.[NH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][N:8]=1>C(OCC)(=O)C>[CH3:5][C:2]1[N:8]2[CH:9]=[C:10]([N+:13]([O-:15])=[O:14])[CH:11]=[CH:12][C:7]2=[N:6][CH:3]=1

Participants

4

Reactant 2

HCID 778882-Amino-5-nitropyridineHCID 3506242-Bromopropanal

Product 1

HCID 218273463-Methyl-6-nitroimidazo[1,2-a]pyridine

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Operations similar to Production Example 1-(2) were conducted using 2-bromopropionaldehyde and 2-amino-5-nitropyridine. The solid whereupon obtained was suspended in ethyl acetate, and washed with saturated aqueous sodium hydrogencarbonate solution to provide the title compound as yellow solid.

Workup

  1. customThe solid whereupon obtained
  2. washwashed with saturated aqueous sodium hydrogencarbonate solution

Sources & evidence

ORD record
ord-08e9c128559343a49cfbb57ed99de03f
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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