2-Chlorocyclohexanone → HCID 23120546, compound

HRID 1784733Notes

Reaction equation

HRID 1784733 reaction equation
Cl[CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=O.[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][N:11]=1>C(OCC)(=O)C>[N+:16]([C:13]1[CH:14]=[CH:15][C:10]2[N:11]([CH:12]=1)[C:3]1[CH2:4][CH2:5][CH2:6][CH2:7][C:2]=1[N:9]=2)([O-:18])=[O:17]

Participants

4

Reactant 2

HCID 132032-ChlorocyclohexanoneHCID 778882-Amino-5-nitropyridine

Product 1

HCID 23120546HCID 23120546, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Operations similar to Production Example 1-(2) were conducted using 2-chlorocyclohexanone and 2-amino-5-nitropyridine. The resulting solid was suspended in ethyl acetate, washed with saturated aqueous sodium hydrogencarbonate solution and purified by silica gel column chromatography (hexane/ethyl acetate=2/1) to provide the title compound as yellow crystals.

Workup

  1. washwashed with saturated aqueous sodium hydrogencarbonate solution
  2. custompurified by silica gel column chromatography (hexane/ethyl acetate=2/1)

Sources & evidence

ORD record
ord-6c35de7734a0408eaf9404625f6f2ad4
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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