6-Chloronicotinic acid → 6-(4-Fluorophenyl)nicotinic acid

HRID 1784744Notes

Reaction equation

HRID 1784744 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>>[F:11][C:12]1[CH:17]=[CH:16][C:15]([C:2]2[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 792226-Chloronicotinic acidHCID 2856454-Fluorophenylboronic acid

Product 1

HCID 227301866-(4-Fluorophenyl)nicotinic acid

Procedure

Operations similar to those of Production Example 14 were conducted using 6-chloronicotinic acid and 4-fluorophenylboronic acid, to provide the title compound as white solid.

Sources & evidence

ORD record
ord-d32d41c62af2483c8f0d709efb1581f4
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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