4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid → HCID 23120563, compound

HRID 1784755Notes

Reaction equation

HRID 1784755 reaction equation
[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1.[F:17][C:18]([F:35])([F:34])[C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][C:28]([C:31](O)=[O:32])=[CH:27][CH:26]=2)=[CH:21][CH:20]=1.[ClH:36].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:36].[CH:1]1([C:4]2[N:5]=[C:6]3[CH:11]=[CH:10][C:9]([NH:12][C:31]([C:28]4[CH:27]=[CH:26][C:25]([C:22]5[CH:23]=[CH:24][C:19]([C:18]([F:17])([F:34])[F:35])=[CH:20][CH:21]=5)=[CH:30][CH:29]=4)=[O:32])=[CH:8][N:7]3[C:15]=2[CH3:16])[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 27827194'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acidHCID 21866389Hydrogen chloride-ethyl acetateHCID 231205162-Cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine

Product 1

HCID 23120563HCID 23120563, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Operations similar to those of Example 1 were conducted using 2-cyclopropyl-3-methyl-6-nitroimidazo[1,2-a]pyridine and 4′-(trifluoromethyl)[1,1′-biphenyl]-4-carboxylic acid. The resulting solid was dissolved in ethyl acetate, followed by addition of 4N hydrochloric acid-ethyl acetate solution and concentration under reduced pressure. The title compound was obtained as white solid.

Sources & evidence

ORD record
ord-67a716d4480145e18f502b905ad0f4c3
Source dataset
uspto-grants-2009_03
Patent number
US07504412B2

Reaction notes

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