Ethyl isocyanate → HCID 135828227, compound

HRID 1784909Notes

Reaction equation

HRID 1784909 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[C:5]([C:17]#[N:18])=[C:4]([S:19][CH2:20][CH2:21][NH2:22])[N:3]=1.[CH2:23]([N:25]=[C:26]=[O:27])C>CN(C=O)C>[NH2:1][C:2]1[N:3]=[C:4]([S:19][CH2:20][CH2:21][NH:22][C:26]([NH:25][CH3:23])=[O:27])[C:5]([C:17]#[N:18])=[C:6]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[CH:14][CH:15]=2)[C:7]=1[C:8]#[N:9]

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 135828224HCID 135828224, compound

Product 1

HCID 135828227HCID 135828227, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

62.2 mg (0.2 mmol) of 2-amino-6-[(2-aminoethyl)sulfanyl]-4-(4-hydroxyphenyl)-3,5-pyridinedicarbonitrile are suspended in 0.4 ml of DMF, and 14.2 mg (0.2 mmol) of ethyl isocyanate are added at room temperature. The mixture is stirred overnight, filtered and purified by preparative HPLC.

Workup

  1. filtrationfiltered
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-fc5e0ee4c1fd4e79a84df5f3682c463b
Source dataset
uspto-grants-2009_03
Patent number
US07504421B2

Reaction notes

Loading…