反应详情

N-(5-chloro-7-iodo-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-morpholin-4ylpropoxy)quinazolin-4-amine was prepared using the method described in example 4 using 4-chloro-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazoline (1.0 g, 2.96 mmol), 5-chloro-7-iodo-1,3-benzodioxol-4-amine (0.97 g, 3.26 mmol) and sodium bis(trimethylsilyl)amide (1.0M in THF, 6.2 ml) in DMF (15 ml). The crude product was obtained as a pale bown solid (1.71 g, 97%) by quenching the reaction mixture with dilute aqueous ammonium chloride solution; Mass Spectrum: M+H+ 599/601.