反应详情

A suspension of [[[(3-nitrophenyl)amino]carbonyl]aminoacetic acid methyl ester (6.9 g, 27 mmol) in 6N aqueous hydrochloride solution (40 mL) and acetone (20 mL) was stirred at reflux overnight. The resulting solution was cooled and concentrated. The resulting yellowish suspension was filtered and the filter cake was washed with water (50 mL), aqueous sodium bicarbonate solution (50 mL), and air-dried to afford the title compound (4.4 g).

1. temperatureat reflux overnight
2. temperatureThe resulting solution was cooled
3. concentrationconcentrated
4. filtrationThe resulting yellowish suspension was filtered
5. washthe filter cake was washed with water (50 mL), aqueous sodium bicarbonate solution (50 mL)
6. customair-dried