3-[4-(1-tert-Butoxycarbonylamino-ethyl)-phenyl]-acrylic acid ethyl ester → HCID 69066102, compound

HRID 1785443Notes

Reaction equation

HRID 1785443 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH:5]=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([CH:13]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH3:14])=[CH:9][CH:8]=1)[CH3:2]>C(O)C.[OH-].[OH-].[Pd+2]>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH:13]([NH:15][C:16]([O:18][C:19]([CH3:20])([CH3:22])[CH3:21])=[O:17])[CH3:14])=[CH:9][CH:8]=1)[CH3:2]

Participants

4

Reactant 1

HCID 690643563-[4-(1-tert-Butoxycarbonylamino-ethyl)-phenyl]-acrylic acid ethyl ester

Product 1

HCID 69066102HCID 69066102, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

Through a mixture of 3-[4-(1-tert-butoxycarbonylamino-ethyl)-phenyl]-acrylic acid ethyl ester (0.22 g, 0.69 mmol) and palladium hydroxide on carbon (100 mg) in ethanol (10 mL) was bubbled hydrogen through a balloon for 17 h. The mixture was filtered through celite and concentrated to afford an off-white solid. M+1=322.

Workup

  1. customwas bubbled hydrogen through a balloon for 17 h
  2. filtrationThe mixture was filtered through celite
  3. concentrationconcentrated
  4. customto afford an off-white solid

Sources & evidence

ORD record
ord-03202a9215ad4d28aa44793bae1ae8ea
Source dataset
uspto-grants-2009_03
Patent number
US07504403B2

Reaction notes

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