Isopropanol → HCID 178479150, compound

Temperature

140 °C

A mixture of 2-hydroxy -1,3-diaminopropane (9.80 g, 108 mmol) and guanidine hydrochloride (10.4 g, 108 mmol) in a 100 mL RBF was heated at 140° C. under nitrogen for 5 h. The reaction mixture, while under vigorous stirring, was let cooled to 100° C. whereby a mixture of iPrOH (5 mL) and CH3CN (5 mL) were added, resulting in the formation of a slurry. After cooled to room temperature, the mixture was filtered and the solid was washed with additional CH3CN (total 30 mL). The solid was further dried under vacuum to yield a white solid. 1H NMR (400 MHz, D2O): 4.21 (m, 1 H), 3.34 (dt, J 15.2, 2.8, 2H), 3.22 (dt, J 15.2, 2.8).

1. temperatureThe reaction mixture, while under vigorous stirring, was let cooled to 100° C. whereby
2. additionwere added
3. customresulting in the formation of a slurry
4. temperatureAfter cooled to room temperature
5. filtrationthe mixture was filtered
6. washthe solid was washed with additional CH3CN (total 30 mL)
7. customThe solid was further dried under vacuum
8. customto yield a white solid

ORD record

ord-a93d0ed17ef24fb492871f8e95ea8aed

Source dataset

uspto-grants-2009_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07504403B2