1-Methylpiperazine → HCID 68904226, compound

HRID 1785736Notes

Reaction equation

HRID 1785736 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]3[C:15]([C:33]([F:36])([F:35])[F:34])=[C:16]([CH2:20][O:21][CH:22]4[CH2:25][N:24]([C:26]([NH:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:23]4)[CH:17]=[CH:18][CH:19]=3)=[CH:10][CH:9]=2)[CH2:6][CH2:5]O[CH2:3][CH2:2]1.ClCC1C=CC(C2C(C(F)(F)F)=C(COC3C[N:55](C(NC(C)(C)C)=O)[CH2:54]3)C=CC=2)=CC=1.CN1CCNCC1>>[CH3:54][N:55]1[CH2:3][CH2:2][N:1]([CH2:7][C:8]2[CH:9]=[CH:10][C:11]([C:14]3[C:15]([C:33]([F:35])([F:34])[F:36])=[C:16]([CH2:20][O:21][CH:22]4[CH2:23][N:24]([C:26]([NH:28][C:29]([CH3:31])([CH3:30])[CH3:32])=[O:27])[CH2:25]4)[CH:17]=[CH:18][CH:19]=3)=[CH:12][CH:13]=2)[CH2:6][CH2:5]1

Participants

4

Reactant 3

HCID 531671-MethylpiperazineHCID 68906069HCID 68906069, compoundHCID 68907467HCID 68907467, compound

Product 1

HCID 68904226HCID 68904226, compoundYield 67%

Procedure

3-[4-(4-methyl-piperazin-1-ylmethyl)phenyl-2-(trifluoromethyl)phenyl]methoxy-N-(tert-butyl)azetidine-1-carboxamide (211) was prepared using the procedure given in Example 146 for compound 196, starting from compound 195 and N-methylpiperazine. Purification through an SCX-2 cartridge afforded the title compound as a white solid (32 mg, 67% yield).

Workup

  1. custom3-[4-(4-methyl-piperazin-1-ylmethyl)phenyl-2-(trifluoromethyl)phenyl]methoxy-N-(tert-butyl)azetidine-1-carboxamide (211) was prepared
  2. customPurification through an SCX-2 cartridge

Sources & evidence

ORD record
ord-c188ddcfad56499c8fe32d91046306f0
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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