Hydrazine hydrate (1:1) → HCID 67549254, compound

HRID 1786237Notes

Reaction equation

HRID 1786237 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[C:7]1=[O:16])C.O.[NH2:19][NH2:20]>C(O)C>[O:16]=[C:7]1[C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=[CH:11][N:6]1[CH2:5][C:4]([NH:19][NH2:20])=[O:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 68405725HCID 68405725, compound

Product 1

HCID 67549254HCID 67549254, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

As described for example 112a, (2-oxo-3-trifluoromethyl-2H-pyridin-1-yl)-acetic acid ethyl ester in ethanol was reacted with hydrazine hydrate (1.2 equivalents) at rt for 72 h. The mixture was concentrated and crystallized from ethanol/diisopropylether and the compound was obtained as a white solid (yield: 95%). MS: m/e=236.3 [M+H]+.

Workup

  1. concentrationThe mixture was concentrated
  2. customcrystallized from ethanol/diisopropylether

Sources & evidence

ORD record
ord-3330386600d7404293cddcb9102ad6e0
Source dataset
uspto-grants-2009_03
Patent number
US07507729B2

Reaction notes

Loading…