反应详情

温度

50 °C

A mixture of 2,4,6-trifluorophenylacetic acid (570 mg, 3.0 mmol), iodoethane (1.56 g, 10 mmol), and potassium carbonate (1.38 g, 10 mmol) in 5 mL of dimethylsulfoxide is stirred at 50° C. for 3 h, and cooled to room temperature. The mixture is partitioned between diethyl ether and water. The organic layer is washed with water and saturated sodium chloride, dried over magnesium sulfate, and filtered through hydrous magnesium silicate. The filtrate is concentrated to give ethyl 2,4,6-trifluorophenylacetate as a light yellow oil (581 mg, 2.66 mmol).

1. temperaturecooled to room temperature
2. customThe mixture is partitioned between diethyl ether and water
3. washThe organic layer is washed with water and saturated sodium chloride
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered through hydrous magnesium silicate
6. concentrationThe filtrate is concentrated