反应详情

To a stirred solution of 7-methoxy-N-methyl-4-phenylspiro[2H-1-benzopyran-2,4′-piperidine] (3.76 g, 11.71 mmol) in anhydrous 1,2-dichloropropane (150 cm3) was added potassium carbonate (4.04 g, 29.23 mmol) and the resulting suspension was cooled in an ice-bath before being treated drop-wise with 1-chloroethyl chloroformate (1.58 cm3, 14.64 mmol). The reaction mixture was heated to reflux overnight and a further portion of 1-chloroethyl chloroformate (0.8 cm3, 7.4 mmol) was added before it was heated to reflux for a further 24 h. Upon cooling, the reaction mixture was filtered through cotton wool which was subsequently washed with dichloromethane (50 cm3) and the volatiles were removed in vacuo. The resulting intermediate was treated with methyl alcohol (200 cm3) and the mixture was heated to reflux overnight. Upon cooling, the volatiles were removed in vacuo before the resulting solid was dissolved in a mixture of dichloromethane (150 cm3) and aqueous sodium carbonate solution (5%, 30 cm3). The organic layer was separated, washed with water (2×50 cm3), dried over sodium sulfate and the solvent was removed in vacuo to afford the title compound as a gum (3.93 g).

1. temperaturethe resulting suspension was cooled in an ice-bath
2. temperatureThe reaction mixture was heated
3. temperatureto reflux overnight
4. temperaturewas heated
5. temperatureto reflux for a further 24 h
6. temperatureUpon cooling
7. filtrationthe reaction mixture was filtered through cotton wool which
8. washwas subsequently washed with dichloromethane (50 cm3)
9. customthe volatiles were removed in vacuo
10. additionThe resulting intermediate was treated with methyl alcohol (200 cm3)
11. temperaturethe mixture was heated
12. temperatureto reflux overnight
13. temperatureUpon cooling
14. customthe volatiles were removed in vacuo before the resulting solid
15. dissolutionwas dissolved in a mixture of dichloromethane (150 cm3) and aqueous sodium carbonate solution (5%, 30 cm3)
16. customThe organic layer was separated
17. washwashed with water (2×50 cm3)
18. dry with materialdried over sodium sulfate
19. customthe solvent was removed in vacuo