反应详情

温度

140 °C

A mixture of 4-chloro-6-(2-furyl)-5H-pyrrolo[3,2-d]pyrimidine (80 mg), 3-chloro-4-(pyridin-2-ylmethoxy)aniline (94 mg) and 1-methyl-2-pyrrolidinone (2.5 mL) was stirred at 140° C. for 2 hrs, poured into water (10 mL) and adjusted to pH 8 with saturated aqueous sodium hydrogen carbonate. The mixture was extracted with ethyl acetate (30 mL×2). The organic layers were combined and dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was subjected to silica gel column chromatography (eluent, hexane:ethyl acetate=1:1→0:1). The object fraction was concentrated under reduced pressure. Chloroform-diisopropyl ether was added to the residue, and the solid was collected by filtration and dried under reduced pressure at 60° C. to give the title compound (71 mg).

1. extractionThe mixture was extracted with ethyl acetate (30 mL×2)
2. dry with materialdried over anhydrous magnesium sulfate
3. concentrationAfter concentration under reduced pressure
4. concentrationThe object fraction was concentrated under reduced pressure
5. additionChloroform-diisopropyl ether was added to the residue
6. filtrationthe solid was collected by filtration
7. customdried under reduced pressure at 60° C.