HCID 86623848, compound → HCID 67361455, compound

HRID 1787419Notes

Reaction equation

HRID 1787419 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([O:14][CH2:15][CH3:16])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:33])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([Br:32])[CH:27]=1)=O)(C)(C)C>C(O)(C(F)(F)F)=O>[Br:32][C:28]1[CH:27]=[C:26]([C:24]2[CH2:23][C:22](=[O:33])[NH:21][C:9]3[CH:10]=[C:11]([C:17]([F:20])([F:19])[F:18])[C:12]([O:14][CH2:15][CH3:16])=[CH:13][C:8]=3[N:7]=2)[CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 1

HCID 86623848HCID 86623848, compound

Product 1

HCID 67361455HCID 67361455, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

) The title compound was prepared from the above described {2-[3-(3-bromo-phenyl)-3-oxo-propionylamino]-5-ethoxy-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (1.459 g, 2.675 mmol) and TFA (10 mL) according to general procedure I step 2. Obtained as a light yellow solid (0.940 g, 82%). MS (ISP) 427.1 [(M+H)+] and 429.1 [(M+2+H)+].

Sources & evidence

ORD record
ord-5440bf8de9da4754ab76a2702ef7c71b
Source dataset
uspto-grants-2009_03
Patent number
US07511033B2

Reaction notes

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