Trifluoroacetic acid → HCID 67361924, compound

HRID 1787421Notes

Reaction equation

HRID 1787421 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]([F:20])([F:19])[F:18])=[CH:10][C:9]=1[NH:21][C:22](=[O:33])[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([Br:32])[CH:27]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:32][C:28]1[CH:27]=[C:26]([C:24]2[CH2:23][C:22](=[O:33])[NH:21][C:9]3[CH:10]=[C:11]([C:17]([F:20])([F:19])[F:18])[C:12]([N:14]([CH3:16])[CH3:15])=[CH:13][C:8]=3[N:7]=2)[CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86623850HCID 86623850, compound

Product 1

HCID 67361924HCID 67361924, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

) The title compound was prepared from the above described {2-[3-(3-bromo-phenyl)-3-oxo-propionylamino]-5-dimethylamino-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (2.2 g, 4.04 mmol) and TFA (15 mL) in DCM (45 mL) according to general procedure I step 2. Obtained as an off-white solid (1.61 g, 93%). MS (ISP) 426.0 [(M+H)+]; mp 193° C. (dec).

Sources & evidence

ORD record
ord-bafa2403e8f54a4599e4d11dcb8b0ccb
Source dataset
uspto-grants-2009_03
Patent number
US07511033B2

Reaction notes

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