Trifluoroacetic acid → HCID 67362277, compound

HRID 1787422Notes

Reaction equation

HRID 1787422 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH2:16][CH:17]([CH3:19])[CH3:18])[CH3:15])[C:11]([C:20]([F:23])([F:22])[F:21])=[CH:10][C:9]=1[NH:24][C:25](=[O:36])[CH2:26][C:27]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([Br:35])[CH:30]=1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:35][C:31]1[CH:30]=[C:29]([C:27]2[CH2:26][C:25](=[O:36])[NH:24][C:9]3[CH:10]=[C:11]([C:20]([F:22])([F:23])[F:21])[C:12]([N:14]([CH2:16][CH:17]([CH3:18])[CH3:19])[CH3:15])=[CH:13][C:8]=3[N:7]=2)[CH:34]=[CH:33][CH:32]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86623851HCID 86623851, compound

Product 1

HCID 67362277HCID 67362277, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

) The title compound was prepared from the above described {2-[3-(3-bromo-phenyl)-3-oxo-propionylamino]-5-(isobutyl-methyl-amino)-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester (1.01 g, 1.72 mmol) and TFA (6.5 mL) in DCM (20 mL) according to general procedure I step 2. Obtained as a white solid (0.65 g, 81%). MS (ISP) 468.0 [(M+H)+]; mp 186° C. (dec).

Sources & evidence

ORD record
ord-eb627504b6aa47ae94aef6195273078e
Source dataset
uspto-grants-2009_03
Patent number
US07511033B2

Reaction notes

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