反应详情

To a suspension of N-(2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide (150 mg, 0.515 mmol) in tetrahydrofuran (4 ml) at 0° C. was added a 4N solution of hydrochloric acid in 1,4-dioxane (2 ml, 8 mmol). The mixture was stirred at room temperature for 1 h, and concentrated under reduced pressure. The resulting residue was triturated with diethyl ether. The resulting precipitate was collected by filtration, washed with ethyl ether, and dried under reduced pressure to give N-(2,3-dihydro-imidazo[1,2-c]quinazolin-5-yl)nicotinamide hydrochloride (192 mg, quantitative).

1. concentrationconcentrated under reduced pressure
2. customThe resulting residue was triturated with diethyl ether
3. filtrationThe resulting precipitate was collected by filtration
4. washwashed with ethyl ether
5. customdried under reduced pressure