反应详情

温度

160 °C

A suspension of N-(8-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide (example 2-22) 3.50 g (10.9 mmol) and sodium sulfide 4.25 g (54.5 mmol) in 1-methyl-2-pyrrolidinone 10 mL was heated to 160° C. for 4 hours (LC-MS indicated complete consumption of the starting material). The mixture was cooled to room temperature and volatile sideproducts were evaporated. The mixture was partitioned between chloroform and 0.5N NaOH solution. The aqueous layer was neutralized and the formed precipitate was collected to give the title compound 2.34 g as off-white solid. Yield 69.9%.

1. customconsumption of the starting material)
2. temperatureThe mixture was cooled to room temperature
3. customvolatile sideproducts were evaporated
4. customThe mixture was partitioned between chloroform and 0.5N NaOH solution
5. customthe formed precipitate was collected