反应详情

温度

120 °C

The suspension of N-(8-Hydroxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide (example 2-1) 70.0 mg (0.23 mmol), N-(2-bromoethyl)pyrrole 47.6 mg (0.27 mmol) and potassium carbonate 126 mg (0.91 mmol) in N,N-dimethylformamide 5 mL was heated in a sealed tube to 120° C. for 3 hours. The reaction mixture was concentrated and partitioned between dichloromethane and water. The organic layer was washed with 0.1N NaOH solution and brine, dried over Na2SO4 and the solvent was evaporated to give the title compound 49.0 mg as off-white solid. Yield 54%.

1. concentrationThe reaction mixture was concentrated
2. custompartitioned between dichloromethane and water
3. washThe organic layer was washed with 0.1N NaOH solution and brine
4. dry with materialdried over Na2SO4
5. customthe solvent was evaporated