2-Amino-4-methylthiazole → HCID 16116929, compound

HRID 1787625Notes

Reaction equation

HRID 1787625 reaction equation
Cl[C:2]1[N:3]=[CH:4][C:5](I)=[C:6]2[C:11]=1[N:10]=[C:9]([CH3:12])[CH:8]=[CH:7]2.[C:14]([C:16]1[CH:21]=[CH:20][C:19](B2OC(C)(C)C(C)(C)O2)=[CH:18][N:17]=1)#[N:15].[NH2:31][C:32]1[S:33][CH:34]=[C:35]([CH3:37])[N:36]=1>>[CH3:12][C:9]1[CH:8]=[CH:7][C:6]2[C:11](=[C:2]([NH:31][C:32]3[S:33][CH:34]=[C:35]([CH3:37])[N:36]=3)[N:3]=[CH:4][C:5]=2[C:19]2[CH:20]=[CH:21][C:16]([C:14]#[N:15])=[N:17][CH:18]=2)[N:10]=1

Participants

4

Reactant 3

HCID 741432-Amino-4-methylthiazoleHCID 164141882-Cyanopyridine-5-boronic acid pinacol esterHCID 576003528-Chloro-5-iodo-2-methyl-[1,7]naphthyridine

Product 1

HCID 16116929HCID 16116929, compound

Procedure

The title compound, MS: m/e=359.1 (M+H+), was prepared in accordance with the general method of example 15 step 1 and step 3 from 8-chloro-5-iodo-2-methyl-[1,7]naphthyridine (Example I), 2-cyanopyridine-5-boronic acid pinacol ester and 2-amino-4-methylthiazole.

Sources & evidence

ORD record
ord-8ac3fdb2e11c45ecb858c06e97b2f356
Source dataset
uspto-grants-2009_03
Patent number
US07511055B2

Reaction notes

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