反应详情

A saturated aqueous NaNO2 (130 mg, 1.89 mmol) solution was added dropwise to a solution of (2E)-3-pentyl-3,7-dihydro-1H-purine-2,6-dione 2-hydrazone (150 mg, 0.63 mmol) in 5% aqueous HCl solution (3 ml) under stirring at room temperature. The mixture was stirred at room temperature for 1 hour. The mixture was neutralized by saturated NaHCO3 solution and extracted by ethyl acetate (3×). The combined organic phases were washed by brine and dried over MgSO4. The filtration and evaporation of solvent gave the desired product (94.6 mg, 60.7%) as white solid. LCMS calculated for C10H14N7O(M+H): 248.1; found: 248.0.

1. stirringThe mixture was stirred at room temperature for 1 hour
2. extractionextracted by ethyl acetate (3×)
3. washThe combined organic phases were washed by brine
4. dry with materialdried over MgSO4
5. filtrationThe filtration and evaporation of solvent