反应详情

The mixture of ethyl 4-bromobutyrate (0.400 g, 2.05 mmole), 4-phenyl-1H-pyrazole (0.296 g, 2.05 mmole) and K2CO3 (0.567 g, 4.10 mmole) in DMF (10 ml) was stirred at room temperature overnight. The reaction mixture was diluted with water (100 ml) and extracted with ethyl acetate (2×). The combined organic phases were washed with water and then brine, dried over Na2SO4, filtered and concentrated to give the crude product, which was purified by preparative to afford the desired product (73 mg, 52%) as colorless oil. LCMS calculated for C15H19N2O2 (M+H): 259; found: 259.1.

1. extractionextracted with ethyl acetate (2×)
2. washThe combined organic phases were washed with water
3. dry with materialbrine, dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated
6. customto give the crude product, which
7. customwas purified by preparative