HRID1787912

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID89652

2-Thiophenecarboxylic acid, 3-amino-, methyl ester

C6H7NO2S

结构：CC(C)(C)OC(=O)N1CCC(Oc2cc(N3CCCC3)ccc2C(=O)O)CC1

HCID57602489

未命名化合物

结构：COC(=O)c1sccc1NC(=O)c1ccc(N2CCCC2)cc1OC1CCN(OC(C)(C)C)C(=C=O)C1

HCID86610258

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1sccc1NC(=O)c1ccc(N2CCCC2)cc1OC1CCN(C(=O)OC(C)(C)C)CC1

HCID57602470

未命名化合物

收率 58%

PROCEDURE

实验过程

Using methods substantially equivalent to those described in Example 12-C, methyl 3-[2-(1-tert-butoxy-carbonylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-thiophene-2-carboxylate was prepared in a 58% yield from 2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoic acid and methyl 3-aminothiophene-2-carboxylate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ab34c9d7e1bb44e1bf823119269e3b8a
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07511066B2
来源说明: uspto-grants-2009_03

反应 SMILES

C(O[N:6]1[CH2:11][CH2:10][CH:9]([O:12][C:13]2[CH:30]=[C:29]([N:31]3[CH2:35][CH2:34][CH2:33][CH2:32]3)[CH:28]=[CH:27][C:14]=2[C:15]([NH:17][C:18]2[CH:22]=[CH:21][S:20][C:19]=2[C:23]([O:25][CH3:26])=[O:24])=[O:16])[CH2:8][C:7]1=C=O)(C)(C)C.[C:38]([O:42][C:43](N1CCC(OC2C=C(N3CCCC3)C=CC=2C(O)=O)CC1)=[O:44])([CH3:41])([CH3:40])[CH3:39].NC1C=CSC=1C(OC)=O>>[C:38]([O:42][C:43]([N:6]1[CH2:7][CH2:8][CH:9]([O:12][C:13]2[CH:30]=[C:29]([N:31]3[CH2:35][CH2:34][CH2:33][CH2:32]3)[CH:28]=[CH:27][C:14]=2[C:15]([NH:17][C:18]2[CH:22]=[CH:21][S:20][C:19]=2[C:23]([O:25][CH3:26])=[O:24])=[O:16])[CH2:10][CH2:11]1)=[O:44])([CH3:41])([CH3:40])[CH3:39]