Methyl 3-amino-2-thiophenecarboxylate → HCID 57602470, compound

HRID 1787912Notes

Reaction equation

C(O[N:6]1[CH2:11][CH2:10][CH:9]([O:12][C:13]2[CH:30]=[C:29]([N:31]3[CH2:35][CH2:34][CH2:33][CH2:32]3)[CH:28]=[CH:27][C:14]=2[C:15]([NH:17][C:18]2[CH:22]=[CH:21][S:20][C:19]=2[C:23]([O:25][CH3:26])=[O:24])=[O:16])[CH2:8][C:7]1=C=O)(C)(C)C.[C:38]([O:42][C:43](N1CCC(OC2C=C(N3CCCC3)C=CC=2C(O)=O)CC1)=[O:44])([CH3:41])([CH3:40])[CH3:39].NC1C=CSC=1C(OC)=O>>[C:38]([O:42][C:43]([N:6]1[CH2:7][CH2:8][CH:9]([O:12][C:13]2[CH:30]=[C:29]([N:31]3[CH2:35][CH2:34][CH2:33][CH2:32]3)[CH:28]=[CH:27][C:14]=2[C:15]([NH:17][C:18]2[CH:22]=[CH:21][S:20][C:19]=2[C:23]([O:25][CH3:26])=[O:24])=[O:16])[CH2:10][CH2:11]1)=[O:44])([CH3:41])([CH3:40])[CH3:39]

Participants

Reactant 3

HCID 89652Methyl 3-amino-2-thiophenecarboxylate

HCID 57602489HCID 57602489, compound

HCID 86610258HCID 86610258, compound

Product 1

HCID 57602470HCID 57602470, compoundYield 58%

Procedure

Using methods substantially equivalent to those described in Example 12-C, methyl 3-[2-(1-tert-butoxy-carbonylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-thiophene-2-carboxylate was prepared in a 58% yield from 2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoic acid and methyl 3-aminothiophene-2-carboxylate.

Sources & evidence

ORD record: ord-ab34c9d7e1bb44e1bf823119269e3b8a
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07511066B2

Reaction notes

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