反应详情

温度

57.5 °C

A mixture of methyl 2,4-dihydroxybenzoate (5.04 g, 30 mmol), 1-bromo-2-fluoroethane (4.18 g, 2.46 mL, 33 mmol), potassium carbonate (4.55 g, 33 mmol) and potassium iodide (1 g) in DMF (20 mL) was heated overnight at 55-60° C. before it was poured into water (150 mL). The resulting white precipitate was filtered, redissolved in dichloromethane, dried (MgSO4), concentrated and diluted with hexane to afford the ether in two crops (1.30 g and 2.19 g). The first crop was characterized:

1. filtrationThe resulting white precipitate was filtered
2. dissolutionredissolved in dichloromethane
3. dry with materialdried (MgSO4)
4. concentrationconcentrated
5. additiondiluted with hexane
6. customto afford the ether in two crops (1.30 g and 2.19 g)