Dichloromethane → 7-methoxy-5-(N-methylpiperidin-4-yloxy)-3-pivaloyloxymethyl-3,4-dihydroquinazolin-4-one

HRID 178798Notes

Reaction equation

HRID 178798 reaction equation
[CH2:50]([Cl:51])[Cl:52].[OH:1][c:2]1[c:3]2[c:4](=[O:22])[n:5]([CH2:14][O:15][C:16]([C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[cH:6][n:7][c:8]2[cH:9][c:10]([O:12][CH3:13])[cH:11]1.[OH:42][CH:43]1[CH2:44][CH2:45][N:46]([CH3:49])[CH2:47][CH2:48]1.[c:23]1([P:24]([c:25]2[cH:26][cH:27][cH:28][cH:29][cH:30]2)[c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[cH:37][cH:38][cH:39][cH:40][cH:41]1>>[O:1]([c:2]1[c:3]2[c:4](=[O:22])[n:5]([CH2:14][O:15][C:16]([C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[cH:6][n:7][c:8]2[cH:9][c:10]([O:12][CH3:13])[cH:11]1)[CH:43]1[CH2:44][CH2:45][N:46]([CH3:49])[CH2:47][CH2:48]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 11776TriphenylphosphineHCID 660484-Piperidinol, 1-methyl-HCID 119745575-Hydroxy-7-methoxy-3-pivaloyloxymethyl-quinazolin-4-one

Product 1

HCID 119739027-methoxy-5-(N-methylpiperidin-4-yloxy)-3-pivaloyloxymethyl-3,4-dihydroquinazolin-4-one

Sources & evidence

ORD record
ord-571b52b6ab574779abb074d810df1997
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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