Hydrochloric Acid → 4-Amino-N-(1,1-dimethylethyl)benzenesulfonamide

HRID 1787989Notes

Reaction equation

HRID 1787989 reaction equation
[CH3:1][C:2]([NH:5][S:6]([C:9]1[CH:14]=[CH:13][C:12]([NH:15]C(=O)C)=[CH:11][CH:10]=1)(=[O:8])=[O:7])([CH3:4])[CH3:3].Cl>[OH-].[Na+]>[CH3:4][C:2]([NH:5][S:6]([C:9]1[CH:10]=[CH:11][C:12]([NH2:15])=[CH:13][CH:14]=1)(=[O:8])=[O:7])([CH3:1])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 668309N-[4-(tert-butylsulfamoyl)phenyl]acetamide

Product 1

HCID 8326274-Amino-N-(1,1-dimethylethyl)benzenesulfonamide

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

N-(1,1-Dimethylethyl)-4-(acetylamino)benzenesulfonamide (Example 11) is deprotected by saponification in 20% NaOH (5 mL), followed by neutralization with 10% HCl. The precipitate that is formed is collected by filtration and recrystallized from methanol/diethyl ether.

Workup

  1. customThe precipitate that is formed
  2. filtrationis collected by filtration
  3. customrecrystallized from methanol/diethyl ether

Sources & evidence

ORD record
ord-ff145d030128435c8c79a13cc1baebb8
Source dataset
uspto-grants-2009_03
Patent number
US07511133B2

Reaction notes

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